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The only remaining mystery is who is the person that heals Bonney up to this point. If Bonney's life, by the doctor's verdict, will end during the beginning of the Straw Hat's journey, there are few plausible theories.
One theory of the cause Kuma voluntarily becomes a test subject is so Vegapunk can cure her diseases should Vegapunk find the cure for her.
As for Bonney, her motive become pirate could be clear enough, to find and rescue Kuma. Assuming Oda's current SBS stated that she's 12 years old, she'll be 10 years old pre-time skip.
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